Oleic acid increased satiety - at least in rats
Fats with unsaturated fatty acids may be able to help you lose weight, researchers have now shown: Once in the small intestine, edible olive oil and give the likes of the body that is the message "Stop eating, you're tired!". The reason for this is mainly oleic acid, a common fatty acid in the small intestine triggers the transmission of the message to the brain. Should confirm that the previously affected only in rats and humans proven signal chain satiety, physicians could develop with the help of this natural appetite control system, new treatments for overweight and obesity.
Earlier researchers had observed that occur after eating the mucous cells in the duodenum and the upper part of the small intestine into action and produce a substance called Oleylethanolamid (OEA). This messenger then forges his way to the nerve endings, which in turn transmit the brain the message that no more food is needed. What triggers this signal chain, however, was not yet known. Therefore supplied Gary Schwartz and his team now rats with various nutrients and observed the response of the mucosal cells.
The result: Only a fat emulsion, but not carbohydrates or proteins, unleashed the OEA formation. In addition, there was only one reaction when the emulsion of oleic acid, a monounsaturated, often contained in vegetable fats occurring fatty acid. This fatty acid docked specifically to receptors on the surface of the intestinal mucosa cells and cranked it to the OEA production. The system, concluded the researchers, is thus a natural appetite control mechanism of the body with which he avoids an excessive fat intake.
The fact that so many people still take fat in excess of might, in the kind of lie in industrially produced food fats used, speculate the researchers: It states that it almost exclusively to saturated fatty acids, which can not detect the control system and thus possibly the natural immunity deal. The researchers now hope to mimic a therapy against obesity, the effect of oleic acid also artificially Sun and pretend the body a false feeling of fullness can be. To help them come here, that the receptors on the docks, oleic acid, were previously the focus of pharmaceutical researchers and therefore are well studied. Alternatively, agents are also used to counteract the degradation of OEA, and so get the feeling of fullness longer. Until then, however, also use to help, especially oleic acid-containing fats.